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Incidence and Seasonality of Respiratory Viruses Causing Acute Respiratory Infections in the Northern United Arab Emirates.BACKGROUND Data on the seasonality of respiratory viruses helps to ensure that vaccinations can be timed optimally and that possible variant outbreaks can be monitored. OBJECTIVES We designed our study to describe the molecular epidemiology and seasonality of acute respiratory infection (ARI)-related respiratory viruses in the United Arab Emirates (UAE). METHODS We collected both upper and lower respiratory specimens for analysis from all patients who visited the Sheikh Khalifa Specialty Hospital (SKSH) with ARI for over 2 years. The multiplex real-time reverse transcription PCR (rRT-PCR) test was used to detect respiratory viruses such as human adenovirus, influenza virus (FLU) A and B, respiratory syncytial virus, parainfluenza viruses, human rhinovirus, human metapneumovirus, human enterovirus, human coronavirus, and human bocavirus. RESULTS We collected 1362 respiratory samples from 733 (53.8%) male and 629 (46.2%) female ARI patients who visited the SKSH between November 2015 and February 2018. The rRT-PCR test revealed an overall positivity rate of 37.2% (507/1362). The positive rate increased during winter; it was highest in December and lowest in September. FLU was the most frequently detected virus (273/1362 [20.0%]), followed by human rhinovirus (146/1362 [10.7%]). The FLU positivity rate showed two peaks, which occurred in August and December. The peak-to-low ratio for FLU was 2.26 (95% confidence interval [CI] 1.52-3.35). CONCLUSIONS The pattern of FLU in the UAE parallels to that of temperate countries. The trend of small peak of FLU in the summer suggests that a semi-seasonal pattern is possible in the UAE.Jeon JH, Han M, Chang HE, Park SS, Lee JW, Ahn YJ,, Hong DJ.BACKGROUND Data on the seasonality of respiratory viruses helps to ensure that vaccinations can be timed optimally and that possible variant outbreaks can be monitored. OBJECTIVES We designed our study to describe the molecular epidemiology and seasonality of acute respiratory infection (ARI)-related respiratory viruses in the United Arab Emirates (UAE). METHODS We collected both upper and lower respiratory specimens for analysis from all patients who visited the Sheikh Khalifa Specialty Hospital (SKSH) with ARI for over 2 years. The multiplex real-time reverse transcription PCR (rRT-PCR) test was used to detect respiratory viruses such as human adenovirus, influenza virus (FLU) A and B, respiratory syncytial virus, parainfluenza viruses, human rhinovirus, human metapneumovirus, human enterovirus, human coronavirus, and human bocavirus. RESULTS We collected 1362 respiratory samples from 733 (53.8%) male and 629 (46.2%) female ARI patients who visited the SKSH between November 2015 and February 2018. The rRT-PCR test revealed an overall positivity rate of 37.2% (507/1362). The positive rate increased during winter; it was highest in December and lowest in September. FLU was the most frequently detected virus (273/1362 [20.0%]), followed by human rhinovirus (146/1362 [10.7%]). The FLU positivity rate showed two peaks, which occurred in August and December. The peak-to-low ratio for FLU was 2.26 (95% confidence interval [CI] 1.52-3.35). CONCLUSIONS The pattern of FLU in the UAE parallels to that of temperate countries. The trend of small peak of FLU in the summer suggests that a semi-seasonal pattern is possible in the UAE. Jeon JH, Han M, Chang HE, Park SS, Lee JW, Ahn YJ,, Hong DJ. Sheikh Khalifa Specialty Hospital Human; influenza; molecular epidemiology; respiratory tract infections; seasons; united arab emirates J Med Virol. Sheikh Khalifa Specialty HospitalSheikh Khalifa Specialty HospitalJ Med Virol. Human; influenza; molecular epidemiology; respiratory tract infections; seasons; united arab emiratesRespiratory VirusN/Ahttps//www.ncbi.nlm.nih.gov/pubmed/309007502019Incidence and Seasonality of Respiratory Viruses Causing Acute Respiratory Infections in the Northern United Arab Emirates.0x01000BE60DE9C7F7DF4B8EA8A830051652C8
Congenital hepatoblastoma in a growing health economy.A 43-year-old woman, whose pregnancy was complicated by the presence of a large single solid intra-abdominal fetal mass, was referred from the private sector into our fetal maternal unit at the Corniche Hospital, Abu Dhabi at 36 weeks postmenstrual age.Investigations subsequently confirmed that this mass was a congenital hepatoblastoma, one of the very rare embryonic tumours. The baby had chemotherapy and surgical excision of the tumour. Fifteen months later, the alpha feto-protein levels remain normal and follow-on MRI scans do not show recurrence or any residual disease.To our knowledge, this is the first case of congenital hepatoblastoma in the United Arab Emirates (UAE). In the UAE, the interphase between private health insurance schemes and medical (public and private) care within a growing health economy enhances access to unique services such as cancer treatments within specialised centres.Ofoegbu BN, Abdel Salam SEE, Diehl WG, Ghosn L.A 43-year-old woman, whose pregnancy was complicated by the presence of a large single solid intra-abdominal fetal mass, was referred from the private sector into our fetal maternal unit at the Corniche Hospital, Abu Dhabi at 36 weeks postmenstrual age.Investigations subsequently confirmed that this mass was a congenital hepatoblastoma, one of the very rare embryonic tumours. The baby had chemotherapy and surgical excision of the tumour. Fifteen months later, the alpha feto-protein levels remain normal and follow-on MRI scans do not show recurrence or any residual disease.To our knowledge, this is the first case of congenital hepatoblastoma in the United Arab Emirates (UAE). In the UAE, the interphase between private health insurance schemes and medical (public and private) care within a growing health economy enhances access to unique services such as cancer treatments within specialised centres. Ofoegbu BN, Abdel Salam SEE, Diehl WG, Ghosn L. Al Corniche Hospital, Abu Dhabi, United Arab Emirates, Sheikh Khalifa Medical city Abu Dhabi Al Corniche Hospital, Abu Dhabi, United Arab Emirates Sheikh Khalifa Medical city Abu Dhabi materno-fetal medicine; neonatal and paediatric intensive care; paediatric oncology; paediatric surgery BMJ Case Rep. Al Corniche Hospital, Abu Dhabi, United Arab EmiratesSheikh Khalifa Medical city Abu Dhabi Al Corniche Hospital, Abu Dhabi, United Arab Emirates, Sheikh Khalifa Medical city Abu DhabiBMJ Case Rep. materno-fetal medicine; neonatal and paediatric intensive care; paediatric oncology; paediatric surgeryHepatoblastoma12(3).https//www.ncbi.nlm.nih.gov/pubmed/308989492019Congenital hepatoblastoma in a growing health economy.0x01000BE60DE9C7F7DF4B8EA8A830051652C8
Prevalence and correlates of diabetes and its comorbidities in four Gulf Cooperation Council countries: evidence from the World Health Survey Plus.BACKGROUND The Gulf Cooperation Council countries are witnessing unprecedented changes due to fast economic development and population growth. The aims of this study were twofold first, to estimate the prevalence of diabetes and its comorbidities; second, to examine the association of sociodemographic risk factors and healthcare service utilisation with diabetes. METHODS Data from the World Health Survey Plus (WHS+) from Kuwait, Oman, Saudi Arabia and the United Arab Emirates were used. The WHS+ is?a nationally representative household survey of the adult population, conducted between 2008 and 2009. Both logistic regression and zero-inflated Poisson models were applied to examine the associations of risk factors, comorbidity and treatment with self-reported diabetes. RESULTS The highest level of diabetes was observed in Kuwait, with 40.8% among the oldest age group. High body mass index, older age and low education were all associated with diabetes in all settings. High levels of comorbidity existed within the diabetic population. Over 50% of diabetics in all countries reported having at least one chronic condition. In Kuwait and Saudi Arabia, one in five diabetics reported having two or more comorbidities. Treatment prevalence was above 80% across all sociodemographic categories. CONCLUSION The burden of diabetes, although high, is not uniform across populations in the four Gulf countries. Differential exposure to risk, such as unhealthy lifestyles, may be creating a disadvantage for certain populations and influencing the co-occurrence of chronic conditions. In response, a multifaceted and patient-centred approach is needed at all levels of healthcare to control and prevent non-communicable diseases.Morgan SA, Ali MM, Channon AA, Al-Sabahi S, Al Suwaidi H, Osman N, Al Salameen M, Khoja T.BACKGROUND The Gulf Cooperation Council countries are witnessing unprecedented changes due to fast economic development and population growth. The aims of this study were twofold first, to estimate the prevalence of diabetes and its comorbidities; second, to examine the association of sociodemographic risk factors and healthcare service utilisation with diabetes. METHODS Data from the World Health Survey Plus (WHS+) from Kuwait, Oman, Saudi Arabia and the United Arab Emirates were used. The WHS+ is?a nationally representative household survey of the adult population, conducted between 2008 and 2009. Both logistic regression and zero-inflated Poisson models were applied to examine the associations of risk factors, comorbidity and treatment with self-reported diabetes. RESULTS The highest level of diabetes was observed in Kuwait, with 40.8% among the oldest age group. High body mass index, older age and low education were all associated with diabetes in all settings. High levels of comorbidity existed within the diabetic population. Over 50% of diabetics in all countries reported having at least one chronic condition. In Kuwait and Saudi Arabia, one in five diabetics reported having two or more comorbidities. Treatment prevalence was above 80% across all sociodemographic categories. CONCLUSION The burden of diabetes, although high, is not uniform across populations in the four Gulf countries. Differential exposure to risk, such as unhealthy lifestyles, may be creating a disadvantage for certain populations and influencing the co-occurrence of chronic conditions. In response, a multifaceted and patient-centred approach is needed at all levels of healthcare to control and prevent non-communicable diseases. Morgan SA, Ali MM, Channon AA, Al-Sabahi S, Al Suwaidi H, Osman N, Al Salameen M, Khoja T. Vulnerable Group Department, Community Development Authority, Dubai, United Arab Emirates Gulf Arab countries; World Health Survey Plus; chronic comorbidity; diabetes; non-communicable disease J Epidemiol Community Health. Vulnerable Group Department, Community Development Authority, Dubai, United Arab EmiratesVulnerable Group Department, Community Development Authority, Dubai, United Arab EmiratesJ Epidemiol Community Health. Gulf Arab countries; World Health Survey Plus; chronic comorbidity; diabetes; non-communicable diseaseDiabetesN/Ahttps//www.ncbi.nlm.nih.gov/pubmed/308944212019Prevalence and correlates of diabetes and its comorbidities in four Gulf Cooperation Council countries: evidence from the World Health Survey Plus.0x01000BE60DE9C7F7DF4B8EA8A830051652C8
HLA class I allele lineages and haplotype frequencies in Arabs of the United Arab Emirates.The high degree of polymorphism of the HLA system provides suitable genetic markers to study the diversity and migration of different world populations and is beneficial for forensic identification, anthropology, transplantation and disease associations. Although the United Arab Emirates (UAE) population of about nine million people is heterogeneous, information is limited for the HLA class I allele and haplotype frequencies of the Bedouin ethnic group. We performed low-resolution PCR-SSP genotyping of three HLA class I loci at HLA-A, -B and -C for 95 unrelated healthy Bedouins from the cities of Al Ain and Abu Dhabi in the UAE. A total of 54 HLA allele lineages were detected; the most frequent low-resolution allele lineages at each HLA locus were A*02 (0.268), B*51 (0.163) and C*07 (0.216). The inferred estimates for the two most frequent HLA-A and HLA-B haplotypes were HLA-A*02 ~ HLA-B*50 (0.070) and HLA-A*02 ~ HLA-B*51 (0.051), and the most frequent 3-locus haplotype was HLA-A*02 ~ HLA-B*50 ~ HLA-C*06 (0.068). The HLA allele lineage frequencies of the UAE Arabs were compared to those previously reported for 70 other world populations, and a strong genetic similarity was detected between the UAE Arabs and the Saudi Arabians from the west with evidence of a limited gene flow between the UAE Arabs and Pakistani across the Gulf from the east, and the UAE Arabs and Omani from the south of the Gulf Peninsula.Kulski JK, AlSafar HS, Mawart A, Henschel A, Tay GK.The high degree of polymorphism of the HLA system provides suitable genetic markers to study the diversity and migration of different world populations and is beneficial for forensic identification, anthropology, transplantation and disease associations. Although the United Arab Emirates (UAE) population of about nine million people is heterogeneous, information is limited for the HLA class I allele and haplotype frequencies of the Bedouin ethnic group. We performed low-resolution PCR-SSP genotyping of three HLA class I loci at HLA-A, -B and -C for 95 unrelated healthy Bedouins from the cities of Al Ain and Abu Dhabi in the UAE. A total of 54 HLA allele lineages were detected; the most frequent low-resolution allele lineages at each HLA locus were A*02 (0.268), B*51 (0.163) and C*07 (0.216). The inferred estimates for the two most frequent HLA-A and HLA-B haplotypes were HLA-A*02 ~ HLA-B*50 (0.070) and HLA-A*02 ~ HLA-B*51 (0.051), and the most frequent 3-locus haplotype was HLA-A*02 ~ HLA-B*50 ~ HLA-C*06 (0.068). The HLA allele lineage frequencies of the UAE Arabs were compared to those previously reported for 70 other world populations, and a strong genetic similarity was detected between the UAE Arabs and the Saudi Arabians from the west with evidence of a limited gene flow between the UAE Arabs and Pakistani across the Gulf from the east, and the UAE Arabs and Omani from the south of the Gulf Peninsula. Kulski JK, AlSafar HS, Mawart A, Henschel A, Tay GK. Khalifa University of Science and Technology, Abu Dhabi HLA-A ; HLA-B ; HLA-C ; Arabian population; MHC class I; alleles frequencies; haplotype frequencies; middle East; phylogenetic tree; population genetics Int J Immunogenet.Khalifa University of Science and Technology, Abu DhabiKhalifa University of Science and Technology, Abu DhabiInt J Immunogenet.HLA-A ; HLA-B ; HLA-C ; Arabian population; MHC class I; alleles frequencies; haplotype frequencies; middle East; phylogenetic tree; population geneticsHLAN/Ahttps//www.ncbi.nlm.nih.gov/pubmed/308928292019HLA class I allele lineages and haplotype frequencies in Arabs of the United Arab Emirates.0x01000BE60DE9C7F7DF4B8EA8A830051652C8
United Arab Emirates dentists' perceptions about the management of broken down first permanent molars and their enforced extraction in children: a questionnaire survey.PURPOSE The broken down first permanent molar (BDFPM) is common in children. Enforced extractions of first permanent molars (EExFPMs) guidelines were published in the United Kingdom (UK) in 2014. We aimed to assess the knowledge and practice of dentists in the United Arab Emirates (UAE) of BDFPMs in children in light of the guidelines. METHODS A cross-sectional sample of UAE-based dentists treating children completed a self-administered questionnaire covering; knowledge and practice of the principle of EExFPMs; to whom dentists would refer in case of BDFPMs; knowledge of the ideal age for EExFPMs (8-10 years) and finally actual awareness of the EExFPMs guidelines. Chi-square tests (p?Dastouri M., Kowash M, Al-Halabi M, Salami A, Khamis AH, Hussein I.PURPOSE The broken down first permanent molar (BDFPM) is common in children. Enforced extractions of first permanent molars (EExFPMs) guidelines were published in the United Kingdom (UK) in 2014. We aimed to assess the knowledge and practice of dentists in the United Arab Emirates (UAE) of BDFPMs in children in light of the guidelines. METHODS A cross-sectional sample of UAE-based dentists treating children completed a self-administered questionnaire covering; knowledge and practice of the principle of EExFPMs; to whom dentists would refer in case of BDFPMs; knowledge of the ideal age for EExFPMs (8-10 years) and finally actual awareness of the EExFPMs guidelines. Chi-square tests (p? Dastouri M., Kowash M, Al-Halabi M, Salami A, Khamis AH, Hussein I. Hamdan Bin Mohammed College of Dental Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai Broken down first permanent molars; Dentists; Enforced extraction; United Arab Emirates Eur Arch Paediatr Dent. Hamdan Bin Mohammed College of Dental Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai Hamdan Bin Mohammed College of Dental Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai Eur Arch Paediatr Dent. Broken down first permanent molars; Dentists; Enforced extraction; United Arab EmiratesFirst permanent molarsN/Ahttps//www.ncbi.nlm.nih.gov/pubmed/308874642019United Arab Emirates dentists' perceptions about the management of broken down first permanent molars and their enforced extraction in children: a questionnaire survey.0x01000BE60DE9C7F7DF4B8EA8A830051652C8
Parameters of Bone and Cardiovascular Health Related to 25-Hydroxyvitamin D Status in Emirati Nationals attending Primary Care and Diabetes services: a retrospective cohort study.Vitamin D deficiency is endemic in people living in the Gulf states. We performed a retrospective analysis of data gathered at the first attendance of 82,396 Emirati nationals to outpatient diabetes, endocrinology and general primary care services at two centres in the United Arab Emirates during 2012-2016. Our aim was to explore associations between vitamin D status and markers of cardiovascular and bone health. In the study population, 67.1% of men and 73.5% of women had serum 25(OH)D of less than 50 nmol/L, with the lowest levels being found in young adults. Among Emirati adults with type 2 diabetes, serum 25(OH)D?Buckley AJ, Barakat MT, Holick MF, Lessan N.Vitamin D deficiency is endemic in people living in the Gulf states. We performed a retrospective analysis of data gathered at the first attendance of 82,396 Emirati nationals to outpatient diabetes, endocrinology and general primary care services at two centres in the United Arab Emirates during 2012-2016. Our aim was to explore associations between vitamin D status and markers of cardiovascular and bone health. In the study population, 67.1% of men and 73.5% of women had serum 25(OH)D of less than 50 nmol/L, with the lowest levels being found in young adults. Among Emirati adults with type 2 diabetes, serum 25(OH)D? Buckley AJ, Barakat MT, Holick MF, Lessan N. Imperial College London Diabetes Centre, Research Department, Abu Dhabi, United Arab Emirates N/A Sci Rep.Imperial College London Diabetes Centre, Research Department, Abu Dhabi, United Arab EmiratesImperial College London Diabetes Centre, Research Department, Abu Dhabi, United Arab EmiratesSci Rep.N/ADiabetes servicesN/Ahttps//www.ncbi.nlm.nih.gov/pubmed/308467932019Parameters of Bone and Cardiovascular Health Related to 25-Hydroxyvitamin D Status in Emirati Nationals attending Primary Care and Diabetes services: a retrospective cohort study.0x01000BE60DE9C7F7DF4B8EA8A830051652C8
Performance of Aeluropus lagopoides (mangrove grass) ecotypes, a potential turfgrass, under high saline conditions.Climate change has become a real threat, and its impacts are being felt throughout the world. Temperature is considered one of the significant elements by the recent consequences of climate change and global warming, specially the salinity which is increased at higher temperature. Turfgrasses are adversely affected due to an increasing trend in salinity. The main aim of this investigation was to find out salt-tolerant ecotypes from native species of UAE to mitigate the salinity problem. Performance of a native grass, Aeluropus lagopoides, was investigated under high saline conditions during the year 2014 under the UAE climatic conditions. The experiment was planned under randomised complete block design (RCBD) with two factors and four replications. During the experiment, 50 ecotypes of Aeluropus lagopoides, alongside Paspalum vaginatum (as control), were tested at different salt levels, i.e. 0, 15, 30, 45, 60 and 75 dSm-1. Significant differences were found among various ecotypes as well as salinity levels for different agronomic traits including green cover, canopy stiffness, leaf colour and salinity of leaf rinseates. Most of the ecotypes tolerated salinity up to 30 dSm-1, maintaining the quality, but beyond this level the quality declined. However, some of the ecotypes survived under high salinity, even beyond sea level (75 dSm-1). All the ecotypes, except RUA2, RUA3 and RUA1, showed better performance than P. vaginatum, the prevailing commercial turfgrass in the UAE. Based on their performance, the ecotypes RUDA7, FA5, RA3, RUDA2 and RA2 could be used for turf purposes under saline conditions.Zamin M, Khattak AM, Salim AM, Marcum KB, Shakur M, Shah S, Jan I, Fahad S.Climate change has become a real threat, and its impacts are being felt throughout the world. Temperature is considered one of the significant elements by the recent consequences of climate change and global warming, specially the salinity which is increased at higher temperature. Turfgrasses are adversely affected due to an increasing trend in salinity. The main aim of this investigation was to find out salt-tolerant ecotypes from native species of UAE to mitigate the salinity problem. Performance of a native grass, Aeluropus lagopoides, was investigated under high saline conditions during the year 2014 under the UAE climatic conditions. The experiment was planned under randomised complete block design (RCBD) with two factors and four replications. During the experiment, 50 ecotypes of Aeluropus lagopoides, alongside Paspalum vaginatum (as control), were tested at different salt levels, i.e. 0, 15, 30, 45, 60 and 75 dSm-1. Significant differences were found among various ecotypes as well as salinity levels for different agronomic traits including green cover, canopy stiffness, leaf colour and salinity of leaf rinseates. Most of the ecotypes tolerated salinity up to 30 dSm-1, maintaining the quality, but beyond this level the quality declined. However, some of the ecotypes survived under high salinity, even beyond sea level (75 dSm-1). All the ecotypes, except RUA2, RUA3 and RUA1, showed better performance than P. vaginatum, the prevailing commercial turfgrass in the UAE. Based on their performance, the ecotypes RUDA7, FA5, RA3, RUDA2 and RA2 could be used for turf purposes under saline conditions. Zamin M, Khattak AM, Salim AM, Marcum KB, Shakur M, Shah S, Jan I, Fahad S. UAE University, Al Ain, UAE. Climate change; Halophytes; Indigenous grass; Sustainable landscaping Environ Sci Pollut Res Int.UAE University, Al Ain, UAE.UAE University, Al Ain, UAE.Environ Sci Pollut Res Int.Climate change; Halophytes; Indigenous grass; Sustainable landscapingSalinityN/Ahttps//www.ncbi.nlm.nih.gov/pubmed/309050182019Performance of Aeluropus lagopoides (mangrove grass) ecotypes, a potential turfgrass, under high saline conditions.0x01000BE60DE9C7F7DF4B8EA8A830051652C8
Eculizumab in paediatric atypical haemolytic uraemic syndrome: Lessons learned from a single-centre experience in the United Arab Emirates.AIM Atypical haemolytic uraemic syndrome (aHUS) is a debilitating condition that can cause significant morbidity and mortality in children if not adequately and promptly treated. This report shares real-world data on the use of eculizumab in children with aHUS. METHODS We report our experience with the use of eculizumab in 14 children with aHUS. RESULTS The median age at aHUS diagnosis was 12?months (range 2-108?months), with six (42.9%) patients presenting in infancy and six (42.9%) being males. Eculizumab therapy was associated with haematological and thrombotic microangiopathy responses in 14 (100%) and 13 (92.9%) patients after a median of 9?days (range 7-12?days) and 9.5?days (range 7-14?days), respectively. None of the six patients who were previously treated with plasma therapy required any further infusions. Of the six patients who previously required dialysis, only one patient continued to do so and eventually received a renal transplant. The median time to =25% decrease in serum creatinine level in the remaining patients was 16?days (range 14-21?days), and estimated glomerular filtration rate increased from a median of 17-101?mL/min/1.73?m2 . The safety profile was similar to that reported in the literature, and 10 patients continue to receive therapy, with 3 being on the drug for 4 or more years. CONCLUSION Our study adds to the growing body of evidence highlighting the efficacy and safety of eculizumab for the management of children with aHUS.Kumar G, Al-Masri O, Alismaili Z, Tawfik E, Al-Ghabra MK, Ilyas SH, Al-Khasawneh E.AIM Atypical haemolytic uraemic syndrome (aHUS) is a debilitating condition that can cause significant morbidity and mortality in children if not adequately and promptly treated. This report shares real-world data on the use of eculizumab in children with aHUS. METHODS We report our experience with the use of eculizumab in 14 children with aHUS. RESULTS The median age at aHUS diagnosis was 12?months (range 2-108?months), with six (42.9%) patients presenting in infancy and six (42.9%) being males. Eculizumab therapy was associated with haematological and thrombotic microangiopathy responses in 14 (100%) and 13 (92.9%) patients after a median of 9?days (range 7-12?days) and 9.5?days (range 7-14?days), respectively. None of the six patients who were previously treated with plasma therapy required any further infusions. Of the six patients who previously required dialysis, only one patient continued to do so and eventually received a renal transplant. The median time to =25% decrease in serum creatinine level in the remaining patients was 16?days (range 14-21?days), and estimated glomerular filtration rate increased from a median of 17-101?mL/min/1.73?m2 . The safety profile was similar to that reported in the literature, and 10 patients continue to receive therapy, with 3 being on the drug for 4 or more years. CONCLUSION Our study adds to the growing body of evidence highlighting the efficacy and safety of eculizumab for the management of children with aHUS. Kumar G, Al-Masri O, Alismaili Z, Tawfik E, Al-Ghabra MK, Ilyas SH, Al-Khasawneh E. Sheikh Khalifa Medical City, Abu Dhabi, Childhood; efficacy; haemolytic anaemia; renal disease; safety J Paediatr Child Health Sheikh Khalifa Medical City, Abu Dhabi, Sheikh Khalifa Medical City, Abu Dhabi, J Paediatr Child HealthChildhood; efficacy; haemolytic anaemia; renal disease; safetyHaemolytic uraemic syndromeN/Ahttps//www.ncbi.nlm.nih.gov/pubmed/307142432019Eculizumab in paediatric atypical haemolytic uraemic syndrome: Lessons learned from a single-centre experience in the United Arab Emirates.0x01000BE60DE9C7F7DF4B8EA8A830051652C8
Multiple Sclerosis, Anxiety, and Depression in the United Arab Emirates: Does Social Stigma Prevent Treatment?Background Depression rates in the multiple sclerosis (MS) population in the Arab world have rarely been reported despite people with MS generally having higher rates of depression. We examined depression rates in 416 people with MS versus the general population of Abu Dhabi, United Arab Emirates, and their treatment. Methods A retrospective medical record review of 416 people with MS (age range, 16–80 years) followed up at four large government hospitals in Abu Dhabi was conducted to determine the percentage of people with MS diagnosed as having depression or anxiety. Results The depression rate in people with MS (10.8%) was close to that in the general population of Abu Dhabi. The adjusted odds ratios of depression by selected variables showed that there was a significant difference (P = .003) between females and males in reporting depression, with more females reporting depression than males. Greater MS duration was also associated with a higher likelihood of being depressed (P = .025). The anxiety rate in the cohort (4.8%) was lower than that in the general Abu Dhabi population (18.7%). Conclusions The depression rate in people with MS in Abu Dhabi was close to that of the general Abu Dhabi population, but the anxiety rate in people with MS was lower. Explanations for these low rates include possible underreporting by patients and physician factors such as time limitations in busy clinics. Cultural aspects such as strong family support systems and religious factors in this predominantly Muslim population are also possible factors that warrant further investigation.Schiess N, Huether K, Holroyd KB, Aziz F, Emam E, Shahrour T, Szolics M, Alsaadi T.Background Depression rates in the multiple sclerosis (MS) population in the Arab world have rarely been reported despite people with MS generally having higher rates of depression. We examined depression rates in 416 people with MS versus the general population of Abu Dhabi, United Arab Emirates, and their treatment. Methods A retrospective medical record review of 416 people with MS (age range, 16–80 years) followed up at four large government hospitals in Abu Dhabi was conducted to determine the percentage of people with MS diagnosed as having depression or anxiety. Results The depression rate in people with MS (10.8%) was close to that in the general population of Abu Dhabi. The adjusted odds ratios of depression by selected variables showed that there was a significant difference (P = .003) between females and males in reporting depression, with more females reporting depression than males. Greater MS duration was also associated with a higher likelihood of being depressed (P = .025). The anxiety rate in the cohort (4.8%) was lower than that in the general Abu Dhabi population (18.7%). Conclusions The depression rate in people with MS in Abu Dhabi was close to that of the general Abu Dhabi population, but the anxiety rate in people with MS was lower. Explanations for these low rates include possible underreporting by patients and physician factors such as time limitations in busy clinics. Cultural aspects such as strong family support systems and religious factors in this predominantly Muslim population are also possible factors that warrant further investigation. Schiess N, Huether K, Holroyd KB, Aziz F, Emam E, Shahrour T, Szolics M, Alsaadi T. UAE University, Al Ain, UAE., Tawam Hospital, Al Ain, American Center for Psychiatry and Neurology, Abu Dhabi UAE University, Al Ain, UAE. Tawam Hospital, Al Ain American Center for Psychiatry and Neurology, Abu Dhabi Anxiety, Depression, Multiple sclerosis (MS), United Arab Emirates Int J MS Care. UAE University, Al Ain, UAE.Tawam Hospital, Al AinAmerican Center for Psychiatry and Neurology, Abu DhabiUAE University, Al Ain, UAE., Tawam Hospital, Al Ain, American Center for Psychiatry and Neurology, Abu DhabiInt J MS Care. Anxiety, Depression, Multiple sclerosis (MS), United Arab EmiratesMultiple Sclerosis, Anxiety, and Depression21(1)https//www.ncbi.nlm.nih.gov/pmc/articles/PMC6390819/2019Multiple Sclerosis, Anxiety, and Depression in the United Arab Emirates: Does Social Stigma Prevent Treatment?0x01000BE60DE9C7F7DF4B8EA8A830051652C8
Occupational noise-induced hearing loss among dental professionals.The purpose of this study was to determine whether the persistent high-frequency noise produced by dental equipment could cause hearing impairment among the dental professionals in the United Arab Emirates (UAE). METHOD AND MATERIALS This cross-sectional study was conducted to evaluate the hearing capacity of 90 randomly selected dental practitioners from different specialties working in the UAE. The participants were approached in their workplace and their hearing capacity was evaluated using the pure tone audiometer. RESULTS Twenty dental practitioners suffered from hearing impairment, which constitutes 22.2% of the studied sample. At high frequencies, left ears were more affected than right ears, but this was not statistically significant. There was a direct relationship between working hours per week and the hearing capacity, but this did not reach a statistically significant level. The lowest hearing capacity was detected in males at a significantly lower value compared to females. CONCLUSIONS Positive correlation was found between years of experience and reduced hearing capacity among dental practitioners. In addition, males had a significantly higher median count of severely affected hearing frequencies compared to females. Online pure tone audiometric testing is an easy, cost-effective tool that can be used to self-assess the hearing capacity of dental professionals, and it is recommended to perform this test annually.Al-Rawi NH, Al Nuaimi AS, Sadiqi A, Azaiah E, Ezzeddine D, Ghunaim Q, Abbas Z.The purpose of this study was to determine whether the persistent high-frequency noise produced by dental equipment could cause hearing impairment among the dental professionals in the United Arab Emirates (UAE). METHOD AND MATERIALS This cross-sectional study was conducted to evaluate the hearing capacity of 90 randomly selected dental practitioners from different specialties working in the UAE. The participants were approached in their workplace and their hearing capacity was evaluated using the pure tone audiometer. RESULTS Twenty dental practitioners suffered from hearing impairment, which constitutes 22.2% of the studied sample. At high frequencies, left ears were more affected than right ears, but this was not statistically significant. There was a direct relationship between working hours per week and the hearing capacity, but this did not reach a statistically significant level. The lowest hearing capacity was detected in males at a significantly lower value compared to females. CONCLUSIONS Positive correlation was found between years of experience and reduced hearing capacity among dental practitioners. In addition, males had a significantly higher median count of severely affected hearing frequencies compared to females. Online pure tone audiometric testing is an easy, cost-effective tool that can be used to self-assess the hearing capacity of dental professionals, and it is recommended to perform this test annually. Al-Rawi NH, Al Nuaimi AS, Sadiqi A, Azaiah E, Ezzeddine D, Ghunaim Q, Abbas Z. University of Sharjah Audiometer; dentist; hearing loss; noise-induced Quintessence Int. University of SharjahUniversity of SharjahQuintessence Int. Audiometer; dentist; hearing loss; noise-inducedHearing loss50(3)https//www.ncbi.nlm.nih.gov/pubmed/307735762019Occupational noise-induced hearing loss among dental professionals.0x01000BE60DE9C7F7DF4B8EA8A830051652C8

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